Thrombotic thrombocytopenic purpura (TTP) is an acute disorder with an estimated incidence of 1-2 cases per million people per year.

The cause of symptoms of TTP is widespread formation of platelet aggregates (thrombi) in the capillaries that results in reduced oxygen supply to tissues of multiple organs (liver, brain, kidney and others).

Clinical features of TTP include thrombocytopenia (low number of circulating platelets) due to consumption of platelets in the formation of aggregates and anemia (low level of circulating hemoglobin) due to fragmentation of red blood cells in the thrombi (hemolytic anemia)