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Delay in treatment increases the risk of adverse outcome, therefore prompt diagnosis is very important.

Diagnosis is made on the basis of clinical symptoms and laboratory tests.
Blood test abnormalities, which are necessary to establish the diagnosis of TTP, are:
- Low level of circulating platelets
- Hemolytic anemia caused by fragmentation of red blood cells

It is important to distinguish TTP from diseases with similar features as HUS, HELLP and others (further details on differential diagnosis can be found in the medical section of this site).

Apart from the fore mentioned clinical symptoms, at the moment there is no specific diagnostic test for TTP. ADAMTS13 plasma levels and presence of autoantibodies anti-ADAMTS13 are being evaluated as possible diagnostic tests, but these do not fulfill the required characteristics for a reliable diagnostic test (there are TTP patients with normal values).

 

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